Autologous Chondrocyte Sheets

CellSeed has conducted joint research on regeneration of knee cartilage (hyaline cartilage) with Professor Masato Sato at Tokai University and has currently manufactured autologous chondrocyte sheets for the Advanced Medicine B program as contracted by Tokai University.

Treatment method

Cells are harvested from the patient's own healthy cartilage tissue and cultured into sheets. The sheets are then stacked in triplicate and transplanted into the defective cartilage area.

2011 - 2014	Autologous chondrocyte sheets were transplanted to eight patients in a clinical research at Tokai University School of Medicine.
2017	Licensing out Autologous cell sheet to MetaTech in Taiwan
2019	Tokai University filed an application at the Advanced Medical Conference held by Japan’s Ministry of Health, Labour and Welfare, and the approval was granted as the Advanced Medicine B program.
2020	Started medical treatment in Tokai University as Advanced Medicine B program. Contract manufacture of autologous chondrocyte sheets started at CellSeed.
As of 2022	Contract manufacture for the Advanced Medicine B program continues.